It has been 5 years since the fourth edition was completed. The fifth edition has some significant organizational changes, as suggested by extensive surveys of faculty and students who used the fourth edition in their classes and studies. The major pedagogic features of the text remain.
They have been enhanced by the following changes for the fifth edition:
1. Every patient history has been reviewed and revised to reflect current standards of care (as of 2016). The patient names have also been changed to a first name and last initial. A key indicating the “old” names and “new” names is available in the online supplement associated with the text.
2. The Biochemical Comments associated with each chapter have been updated, where appropriate, to allow students to experience where current research efforts are headed.
3. The presentation of metabolism has been altered such that glycolysis is now the first topic discussed, followed by the tricarboxylic acid cycle, and then oxidative phosphorylation. The correlation between fourth edition chapters and fifth edition chapters are as follows: a. Chapters 1 through 18, no change b. Section IV is now entitled “Carbohydrate Metabolism, Fuel Oxidation, and the Generation of Adenosine Triphosphate” and consists of Chapters 19 through 28.
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